Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity
نویسندگان
چکیده
منابع مشابه
Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity
Amyloid beta (Aβ) peptide aggregation is linked to the initiation of Alzheimer's disease; accordingly, aggregation-prone isoforms of Aβ, expressed in the brain, shorten the lifespan of Drosophila melanogaster. However, the lethal effects of Aβ are not apparent until after day 15. We used shibire(TS) flies that exhibit a temperature-sensitive paralysis phenotype as a reporter of proteostatic rob...
متن کاملThe novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity☆
Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...
متن کاملInhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity.
The accumulation of beta-amyloid peptides (Abeta) into senile plaques is one of the hallmarks of Alzheimer disease. Aggregated Abeta is toxic to cells in culture and this has been considered to be the cause of neurodegeneration that occurs in the Alzheimer disease brain. The discovery of compounds that prevent Abeta toxicity may lead to a better understanding of the processes involved and ultim...
متن کاملSynaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction.
There is growing evidence that mild cognitive impairment in early AD (Alzheimer's disease) may be due to synaptic dysfunction caused by the accumulation of non-fibrillar, oligomeric Abeta (amyloid beta-peptide), long before widespread synaptic loss and neurodegeneration occurs. Soluble Abeta oligomers can rapidly disrupt synaptic memory mechanisms at extremely low concentrations via stress-acti...
متن کاملAmyloid Peptide Toxicity in an Animal Model of Alzheimer Disease
November 2007 | Volume 5 | Issue 11 | e313 Acting as motors, pumps, switches, catalysts, and in numerous other roles, proteins perform nearly all the functions of a cell. This staggering functional diversity arises from linking just 20 amino acids in seemingly endless permutations to form polypeptide chains. The sequence of amino acids in the polypeptide chain determines a protein’s precise 3D ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2016
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2016.01.009